effects of long-term exposure to hydrogen sulfide on human red blood cells

نویسندگان

a saeedi department of pharmacology and toxicology, school of pharmacy, shiraz university of medical sciences, shiraz, iran

a najibi department of pharmacology and toxicology, school of pharmacy, shiraz university of medical sciences, shiraz, iran

a mohammadi-bardbori department of pharmacology and toxicology, school of pharmacy, shiraz university of medical sciences, shiraz, iran

چکیده

background: hydrogen sulfide (h 2 s) exhibits both physiological and toxicological roles in the biological systems. acute exposure to high levels of h 2 s is life threatening while long-term exposure to ambient levels of h 2 s elicits human health effects. objective: to study the harmful effects of long-term exposure to low levels of h 2 s on human blood cells. methods: 110 adult workers from iran who were occupationally exposed to 0–90 ppb h 2 s for 1–30 years were studied. the participants aged between 18 and 60 years and were exposed directly or indirectly to sulfur compounds (exposed group). the origin of h 2 s was natural gas processing plants. a control group consisting of 110 males who were not in contact with h 2 s was also studied. for all participants, hematological profile including total hemoglobin and red blood cell count and sulfhemoglobin, methemoglobin levels were measured. results: among all parameters evaluated in this study the mean methemoglobin and sulfhemoglobin levels were significantly higher among workers who were exposed to sulfur compounds than the control group. major differences throughout the study period for sulfhemoglobinemia among exposed groups were observed. conclusion: long-term exposure to even low levels of h 2 s in workplaces may have potential harmful effects on human health.

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Effects of long-term exposure to hydrogen sulfide on human red blood cells.

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عنوان ژورنال:
international journal of occupational and environment medicine

جلد ۶، شماره ۱ January، صفحات ۴۸۲-۲۰

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